Journal article

CD4( ) CD25( ) regulatory T cells modulate the T-cell and antibody responses in Helicobacter-infected BALB/c mice

Maria Kaparakis, Karen L Laurie, Odilia Wijburg, John Pedersen, Martin Pearse, Ian R van Driel, Paul A Gleeson, Richard A Strugnell

INFECTION AND IMMUNITY | AMER SOC MICROBIOLOGY | Published : 2006

Abstract

Gastric Helicobacter spp. induce chronic gastritis that may lead to ulceration and dysplasia. The host elicits a T helper 1 (Th1) response that is fundamental to the pathogenesis of these bacteria. We analyzed immune responses in Helicobacter-infected, normal mice depleted of CD4+ CD25+ T cells to investigate the in vivo role of regulatory T cells (Tregs) in the modulation of Helicobacter immunopathology. BALB/c and transgenic mice were depleted of CD4+ CD25+ T cells by administration of an anti-CD25 antibody either at the time of infection with Helicobacter or during chronic infection and gastritis. Depletion of CD25+ Tregs prior to and during infection of mice with Helicobacter spp. did no..

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