Journal article

Increased serotonin receptor availability in human sleep: Evidence from an [F-18]MPPF PET study in narcolepsy

C Derry, C Benjamin, P Bladin, D le Bars, H Tochon-Danguy, SF Berkovic, L Zimmer, N Costes, R Mulligan, D Reutens

NEUROIMAGE | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2006

Abstract

Data from animal studies suggest that serotonin release promotes wakefulness and suppresses REM sleep, but there are dangers in extrapolating these findings to humans. Binding of the radioligand [18F]MPPF to 5HT1A receptors is sensitive to levels of endogenous serotonin. In this study, we aimed to demonstrate changes in serotonin receptor availability in the human brain in wakefulness and sleep using [18F]MPPF and positron emission tomography. 14 subjects with narcolepsy cataplexy underwent [18F]MPPF PET scans in wakefulness and in sleep. Subjects who used the stimulant methylphenidate took their normal medication for the wake scan but omitted it prior to the sleep scan. The change in bindin..

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