Body size and composition and prostate cancer risk: systematic review and meta-regression analysis

Abstract

The evidence that measures of obesity and stature are associated with prostate cancer is weak and inconsistent. We performed a systematic review and meta-analysis of the relationship between body mass index (BMI), height, weight, waist circumference and waist-to-hips ratio (WHR) and the risk of prostate cancer. Study-specific dose-response slopes were obtained, and random effects rate ratios (RRs) were computed from linear meta-regression models. We included 55,521 cases identified among 2,818,767 men from 31 cohort studies, and 13,232 cases and 16,317 controls from 25 case-control studies. The overall RR for BMI was 1.05 per 5 kg/m2 increment, 95% CI 1.01-1.08. For studies that reported res..