Journal article

TGF-beta(1) induces IL-8 and MCP-1 through a connective tissue growth factor-independent pathway

W Qi, XM Chen, TS Polhill, S Sumual, S Twigg, RE Gilbert, CA Pollock

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY | AMER PHYSIOLOGICAL SOC | Published : 2006

Abstract

Transforming growth factor-beta(1) (TGF-beta(1)) functions as an important immunomodulatory cytokine in human kidney. Evidence suggests that connective tissue growth factor (CTGF) is an important downstream mediator of the profibrotic effects of TGF-beta(1). However, the role of CTGF in TGF-beta(1)-induced chemokine production remains unknown. This study was undertaken to determine whether CTGF is involved in mediating TGF-beta(1)-induced chemokine production in renal proximal tubular (HK-2) cells. Interleukin-8 (IL-8) and macrophage chemoattractant protein-1 (MCP-1) were measured. TGF-beta(1) induced an increase in IL-8 and MCP-1 (both P < 0.05) compared with control levels. CTGF was effect..

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