Journal article

Evidence-based medicine: Classifying the evidence from clinical trials - the need to consider other dimensions

Rinaldo Bellomo, Sean M Bagshaw

CRITICAL CARE | BMC | Published : 2006


The current approach to assessing the quality of evidence obtained from clinical trials focuses on three dimensions: the quality of the design (with double-blinded randomised controlled trials representing the highest level of such design); the statistical power (beta) and the level of significance (alpha). While these aspects are important, we argue that other significant aspects of trial quality impinge upon the truthfulness of the findings: biological plausibility, reproducibility and generalisability. We present several recent studies in critical care medicine where the design, beta and alpha components of the study are seemingly satisfactory but where the aspects of biological plausibil..

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University of Melbourne Researchers