Journal article

Convergent evolution of receptors for protein import into mitochondria

AJ Perry, JM Hulett, VA Likic, T Lithgow, PR Gooley

CURRENT BIOLOGY | CELL PRESS | Published : 2006

Abstract

BACKGROUND: Mitochondria evolved from intracellular bacterial symbionts. Establishing mitochondria as organelles required a molecular machine to import proteins across the mitochondrial outer membrane. This machinery, the TOM complex, is composed of at least seven component parts, and its creation and evolution represented a sizeable challenge. Although there is good evidence that a core TOM complex, composed of three subunits, was established in the protomitochondria, we suggest that the receptor component of the TOM complex arose later in the evolution of this machine. RESULTS: We have solved by nuclear magnetic resonance the structure of the presequence binding receptor from the TOM compl..

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University of Melbourne Researchers