Journal article

Adverse effects of antiretroviral drugs on HIV-1-infected and -uninfected human monocyte-derived macrophages

R Azzam, L Lal, SL Goh, K Kedzierska, A Jaworowski, E Naim, CL Cherry, SL Wesselingh, J Mills, SM Crowe

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES | LIPPINCOTT WILLIAMS & WILKINS | Published : 2006

Abstract

Antiretroviral drugs approved for treatment of HIV-1 infection include nucleoside reverse transcriptase inhibitors (NRTIs) and protease inhibitors (PIs). Use of these drugs in combinations (highly active antiretroviral therapy) has delayed disease progression. However, long-term therapy is associated with potentially serious adverse effects. NRTIs are thought to contribute to these adverse effects via depletion of mtDNA. Inasmuch as macrophages (major targets for HIV-1) are highly metabolically active with large numbers of mitochondria, we investigated the effects of NRTIs (didanosine, stavudine, lamivudine, and zidovudine) on the viability and function of HIV-1-infected and -uninfected huma..

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