Journal article

WNT/Frizzled signaling in eye development and disease

Robb U de Iongh, Helen E Abud, Gary R Hime

FRONTIERS IN BIOSCIENCE-LANDMARK | FRONTIERS IN BIOSCIENCE INC | Published : 2006

Abstract

The canonical Wnt/Fzd signaling pathway is highly conserved among various species. Increasing evidence is accumulating for non-canonical Wnt signaling pathways, analogous to those discovered in Drosophila, being operative in vertebrates. Similarly, the networks of genes involved in eye development show significant conservation during evolution. The amenability of Drosophila for genetic manipulation and analysis of ocular phenotypes has delivered a great deal of information about the roles of the Wnt/Fzd signaling pathways at various stages of ocular development and growth, particularly in regulating the formation and size of the eye field, cell proliferation, polarity and differentiation. In..

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