Journal article

Hyperchloremic acidosis in the critically ill: One of the strong-ion acidoses?

DA Story, H Morimatsu, R Bellomo

ANESTHESIA AND ANALGESIA | LIPPINCOTT WILLIAMS & WILKINS | Published : 2006

Abstract

Decreases in plasma bicarbonate are associated with hyperchloremic acidosis and lactic acidosis. According to the Stewart approach to acid-base physiology, the strong-ion difference regulates plasma bicarbonate, with chloride and lactate being the only strong anions routinely measured in clinical chemistry. We hypothesized that the plasma strong-ion difference, both with and without lactate, would have a stronger association with plasma bicarbonate than plasma chloride alone would have with bicarbonate. We used plasma acid-base data from 300 critically ill patients. The correlation with bicarbonate became progressively weaker (P < 0.001): all measured strong ions, r = 0.60; measured strong i..

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