Journal article

Population pharmacokinetics of artesunate and dihydroartemisinin following intra-rectal dosing of artesunate in malaria patients

Julie A Simpson, Tsiri Agbenyega, Karen I Barnes, Gianni Di Perri, Peter Folb, Melba Gomes, Sanjeev Krishna, Srivicha Krudsood, Sornchai Looareesuwan, Sharif Mansor, Helen McIlleron, Raymond Miller, Malcolm Molyneux, James Mwenechanya, Visweswaran Navaratnam, Francois Nosten, Piero Olliaro, Lorrin Pang, Isabela Ribeiro, Madalitso Tembo Show all

PLOS MEDICINE | PUBLIC LIBRARY SCIENCE | Published : 2006

Abstract

BACKGROUND: Intra-rectal artesunate has been developed as a potentially life-saving treatment of severe malaria in rural village settings where administration of parenteral antimalarial drugs is not possible. We studied the population pharmacokinetics of intra-rectal artesunate and the relationship with parasitological responses in patients with moderately severe falciparum malaria. METHODS AND FINDINGS: Adults and children in Africa and Southeast Asia with moderately severe malaria were recruited in two Phase II studies (12 adults from Southeast Asia and 11 children from Africa) with intensive sampling protocols, and three Phase III studies (44 children from Southeast Asia, and 86 children ..

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