Journal article

Morphology of breast cancer as a means of triage of patients for BRCA1 genetic testing

Gelareh Farshid, Rosemary L Balleine, Margaret Cummings, Paul Waring

AMERICAN JOURNAL OF SURGICAL PATHOLOGY | LIPPINCOTT WILLIAMS & WILKINS | Published : 2006

Abstract

BACKGROUND: Women who have germline mutations in the BRCA1 gene are at substantially increased lifetime risk of developing breast and ovarian cancer but are otherwise normal. Currently, early age of onset of cancer and a strong family history are relied upon as the chief clues as to who should be offered genetic testing. Certain morphologic and immunohistochemical features are overrepresented in BRCA1-associated breast cancers but these differences have not been incorporated into the current selection criteria for genetic testing. DESIGN: Each of the 4 pathologists studied 30 known cases of BRCA1- and BRCA2-associated breast cancer from kConFab families. After reviewing the literature, we ag..

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