Preparation of the central tryptophan moiety of the celogentin/moroidin family of anti-mitotic cyclic peptides

Abstract

The central functionalized tryptophan core of the celogentin/moroidin family of cyclic peptides has been prepared. The strategy incorporates a novel preparation of 4-iodobenzaldehyde and employs a Larock annulation as the key step. © CSIRO 2006.