Journal article
Effect of low-dose vasopressin infusion on vital organ blood flow in the conscious normal and septic sheep
D Di Giantomasso, H Morimatsu, R Bellomo, CN May
ANAESTHESIA AND INTENSIVE CARE | AUSTRALIAN SOC ANAESTHETISTS | Published : 2006
Abstract
The effect of low-dose vasopressin (AVP) on vital regional circulations may be clinically relevant but has not been fully described. We sought to determine the effect of low-dose AVP on systemic haemodynamics, coronary, mesenteric and renal circulations in the conscious normal and septic mammal. We studied seven Merino sheep using a prospective randomized cross-over double-blind placebo-controlled animal design. We inserted flow probes around aorta, coronary, mesenteric and renal arteries and, three weeks later, we infused low-dose AVP (0.02 IU/min) or placebo in the normal and septic state induced by intravenous E. coli. In normal sheep, AVP (0.02 IU/min) induced a 17% decrease in mesenteri..
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