Journal article

The biology of vascular endothelial growth factor-B (VEGF-B)

AD Nash, M Baca, C Wright, PD Scotney

PULMONARY PHARMACOLOGY & THERAPEUTICS | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | Published : 2006

Abstract

The formation of new blood vessels (angiogenesis) is critical for both embryonic development and a variety of normal postnatal physiological processes. Various pathological processes, most notably tumour growth and chronic inflammation, are also known to be dependent on the new vessel formation. Amongst the variety of factors that contribute to the regulation of this complex process, vascular endothelial growth factor (VEGF or VEGF-A) is arguably the most well characterised. The VEGF family of growth factors is now known to comprise of VEGF-A plus four additional members, including VEGF-B. In contrast to VEGF-A, surprisingly little is known about the precise biological role of VEGF-B. Unlike..

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