Cardiac hypertrophy, substrate utilization and metabolic remodelling: Cause or effect?
RH Ritchie, LMD Delbridge
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY | WILEY | Published : 2006
1. Metabolic remodelling in the heart occurs in response to chronically altered workload and substrate availability. Recently, the importance of the metabolic remodelling processes inherent in the hypertrophic growth response (whether primary or secondary) has been recognized. 2. Altered energy demand, shifts in substrate utilization and increased oxidative stress are observed in the hypertrophic heart. Both a shift away from carbohydrate usage (i.e. insulin resistance) and a shift to carbohydrate usage (i.e. pressure loading) are associated with disturbed cardiomyocyte Ca(2+) homeostasis and the development of cardiac hypertrophy. 3. A change in the balance of myocardial usage of fatty acid..View full abstract