Journal article

Signal therapy of human pancreatic cancer and NF1-deficient breast cancer xenograft in mice by a combination of PP1 and GL-2003, anti-PAK1 drugs (Tyr-kinase inhibitors)

Yumiko Hirokawa, Alexander Levitzki, Guillaume Lessene, Jonathan Baell, Yi Xiao, Hongjian Zhu, Hiroshi Maruta

Cancer Letters | ELSEVIER IRELAND LTD | Published : 2007

DOI: 10.1016/j.canlet.2006.01.018

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34Web of Science
30Scopus

Keywords

Science & Technology
Signal Transduction
Nitriles
Mice, Inbred Balb C
Time Factors
Xenograft Model Antitumor Assays
Histone Deacetylase Inhibitor
Treatment Outcome
Pyrimidines
Fk228
Dose-Response Relationship, Drug
Pancreatic Neoplasms
Growth
Cell Proliferation
Pp1
Depsipeptides
Ras
Mice
Cells
Antineoplastic Combined Chemotherapy Protocols
Mice, Nude
In-Vitro
Family Kinases
Pyrazoles
Src-Family Kinases
Transformation
Mammary Neoplasms, Experimental
Pancreatic Cancers
Gl-2003
Cell Line, Tumor
Enzyme Inhibitors
Life Sciences & Biomedicine
Neurofibromin 1
Neurofibromatosis
Pak1
Protein-Tyrosine Kinases
Drug Synergism
Oncology
Activation
Humans
Src Tyrosine Kinase
Animals
Molecular Structure
Antineoplastic Agents
Quaternary Ammonium Compounds
Breast Neoplasms