Journal article

Signal therapy of human pancreatic cancer and NF1-deficient breast cancer xenograft in mice by a combination of PP1 and GL-2003, anti-PAK1 drugs (Tyr-kinase inhibitors)

Yumiko Hirokawa, Alexander Levitzki, Guillaume Lessene, Jonathan Baell, Yi Xiao, Hongjian Zhu, Hiroshi Maruta

Cancer Letters | ELSEVIER IRELAND LTD | Published : 2007

DOI: 10.1016/j.canlet.2006.01.018

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33Web of Science
30Scopus

Keywords

Protein-Tyrosine Kinases
Cell Line, Tumor
Science & Technology
In-Vitro
Life Sciences & Biomedicine
Cell Proliferation
Treatment Outcome
Activation
Mice, Inbred Balb C
Pyrazoles
Pyrimidines
Pak1
Dose-Response Relationship, Drug
Fk228
Pancreatic Neoplasms
Ras
Histone Deacetylase Inhibitor
Signal Transduction
Nitriles
Mice
Oncology
Neurofibromin 1
Animals
Pp1
Mice, Nude
Family Kinases
Neurofibromatosis
Src-Family Kinases
Pancreatic Cancers
Molecular Structure
Depsipeptides
Antineoplastic Combined Chemotherapy Protocols
Drug Synergism
Cells
Xenograft Model Antitumor Assays
Src Tyrosine Kinase
Breast Neoplasms
Mammary Neoplasms, Experimental
Humans
Gl-2003
Antineoplastic Agents
Transformation
Enzyme Inhibitors
Quaternary Ammonium Compounds
Time Factors
Growth