Journal article

Dysfunction of dorsolateral prefrontal cortex in antipsychotic-naive schizophreniform psychosis

Ben J Harrison, Murat Yucel, Marnie Shaw, Warrick J Brewer, Pradeep J Nathan, Stephen C Strother, James S Olver, Gary F Egan, Dennis Velakoulis, Patrick D McGorry, Christos Pantelis

PSYCHIATRY RESEARCH-NEUROIMAGING | ELSEVIER IRELAND LTD | Published : 2006

Abstract

Reports of abnormal activation of the dorsolateral prefrontal cortex (dlPFC) are common in functional neuroimaging studies of schizophrenia, although very few have examined brain activity in patients close to the onset of illness. In this H(2)(15)O PET study, eight young male patients with first-episode schizophreniform psychosis and age-matched control subjects performed a version of the Stroop task that we have previously shown to engage the middle-frontal gyrus. At the time of testing, patients were antipsychotic-naïve and were scanned within 1 week of initial contact with our clinical program. All patients received a later diagnosis of schizophrenia 6 months after participating in the st..

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