Journal article
Differential expression of Aspergillus nidulans ammonium permease genes is regulated by GATA transcription factor AreA
BJ Monahan, MC Askin, MJ Hynes, MA Davis
EUKARYOTIC CELL | AMER SOC MICROBIOLOGY | Published : 2006
Abstract
The movement of ammonium across biological membranes is mediated in both prokaryotes and eukaryotes by ammonium transport proteins (AMT/MEP) that constitute a family of related sequences. We have previously identified two ammonium permeases in Aspergillus nidulans, encoded by the meaA and mepA genes. Here we show that meaA is expressed in the presence of ammonium, consistent with the function of MeaA as the main ammonium transporter required for optimal growth on ammonium as a nitrogen source. In contrast, mepA, which encodes a high-affinity ammonium permease, is expressed only under nitrogen-limiting or starvation conditions. We have identified two additional AMT/MEP-like genes in A. nidula..
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