Journal article

Differential expression of Aspergillus nidulans ammonium permease genes is regulated by GATA transcription factor AreA

BJ Monahan, MC Askin, MJ Hynes, MA Davis

Eukaryotic Cell | AMER SOC MICROBIOLOGY | Published : 2006


The movement of ammonium across biological membranes is mediated in both prokaryotes and eukaryotes by ammonium transport proteins (AMT/MEP) that constitute a family of related sequences. We have previously identified two ammonium permeases in Aspergillus nidulans, encoded by the meaA and mepA genes. Here we show that meaA is expressed in the presence of ammonium, consistent with the function of MeaA as the main ammonium transporter required for optimal growth on ammonium as a nitrogen source. In contrast, mepA, which encodes a high-affinity ammonium permease, is expressed only under nitrogen-limiting or starvation conditions. We have identified two additional AMT/MEP-like genes in A. nidula..

View full abstract