Journal article

Decreased phosphatidylethanolamine binding protein expression correlates with A beta accumulation in the Tg2576 mouse model of Alzheimer's disease

AJ George, RMD Holsinger, CA McLean, SS Tan, HS Scott, T Cardamone, R Cappai, CL Masters, QX Li

NEUROBIOLOGY OF AGING | ELSEVIER SCIENCE INC | Published : 2006

Abstract

Phosphatidylethanolamine binding protein (PEBP) is a multifunctional protein, with proposed roles as the precursor protein of hippocampal cholinergic neurostimulating peptide (HCNP), and as the Raf kinase inhibitor protein (RKIP). Previous studies have demonstrated a decrease in PEBP mRNA in CA1 region of AD hippocampus. The current study demonstrates that PEBP is decreased in the hippocampus of 11 month Tg2576 mice, in the absence of change in mRNA levels compared to non-transgenic littermates. The level of PEBP in transgenic mouse hippocampus significantly decreases at 11 months (a time point when Abeta begins accumulating) and 15 months (when Abeta plaques have formed). There was a signif..

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