Journal article

Anterior cingulate activation in antipsychotic-naive first-episode schizophrenia

M Yuecel, WJ Brewer, BJ Harrison, A Fornito, GJ O'Keefe, J Olver, AM Scott, GF Egan, D Velakoulis, PD McGorry, C Pantelis

ACTA PSYCHIATRICA SCANDINAVICA | WILEY | Published : 2007

Abstract

UNLABELLED: Anterior cingulate (ACC) hypo-activity is commonly observed in chronically ill schizophrenia patients. However, it is unclear whether this is secondary to persistent illness and/or medication. METHOD: We examined eight antipsychotic-naïve first-episode patients and matched healthy controls undergoing PET scanning while performing the Stroop task. RESULTS: Group-averaged and single-subject analyses showed ACC activation in both controls and patients, albeit in different sub-regions (paracingulate and cingulate respectively). A direct comparison revealed relative under-activity of the left paracingulate cortex in patients. CONCLUSION: These findings suggest that the more pervasive ..

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