Journal article
Ligation of the cell receptor, CD46, alters T cell polarity and response to antigen presentation
J Oliaro, A Pasam, NJ Waterhouse, KA Browne, MJ Ludford-Menting, JA Trapani, SM Russell
Proceedings of the National Academy of Sciences of the United States of America | Published : 2006
Abstract
Lymphocyte function in vivo is dictated by multiple external cues, but the integration of different signals is not well understood. Here, we show that competition for the axis of polarization dictates functional outcomes. We investigated the effect of ligation of the immunoregulatory cell surface receptor, CD46, on lymphocyte polarity during antigen presentation and cytotoxic effector function. Ligation of CD46 on human T cells prevented recruitment of the microtubule organizing center, CD3, and perform to the interface with the antigen-presenting cell and caused a reduction in IFN-γ production. In human NK cells, similar changes in polarity induced by CD46 ligation inhibited the recruitment..
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