Journal article

Pathophysiologic implications of reduced podocyte number in a rat model of progressive glomerular injury

D Macconi, M Bonomelli, A Benigni, T Plati, F Sangalli, L Longaretti, S Conti, H Kawachi, P Hill, G Remuzzi, A Remuzzi

AMERICAN JOURNAL OF PATHOLOGY | AMER SOC INVESTIGATIVE PATHOLOGY, INC | Published : 2006

Abstract

Changes in podocyte number or density have been suggested to play an important role in renal disease progression. Here, we investigated the temporal relationship between glomerular podocyte number and development of proteinuria and glomerulosclerosis in the male Munich Wistar Fromter (MWF) rat. We also assessed whether changes in podocyte number affect podocyte function and focused specifically on the slit diaphragm-associated protein nephrin. Age-matched Wistar rats were used as controls. Estimation of podocyte number per glomerulus was determined by digital morphometry of WT1-positive cells. MWF rats developed moderate hypertension, massive proteinuria, and glomerulosclerosis with age. Glo..

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University of Melbourne Researchers