Journal article

Preoperative folate and homocysteine status in patients undergoing major surgery

Paul S Myles, Matthew TV Chan, Andrew Forbes, Kate Leslie, Michael Paech, Philip Peyton

CLINICAL NUTRITION | CHURCHILL LIVINGSTONE | Published : 2006

Abstract

BACKGROUND & AIMS: Patients with folate deficiency and elevated homocysteine (Hcy) levels have increased risk of cerebrovascular and cardiovascular disease. They may also be at increased risk of complications after surgery because nitrous oxide interferes with folate metabolism. The aim of this study was to assess the incidence of folate deficiency and hyperhomocysteinemia in patients presenting for major surgery. We also tested the utility of a brief preoperative medical and dietary questionnaire to identify those with low folate or elevated Hcy levels. METHODS: We enrolled 390 patients and obtained a preoperative fasting blood sample from each of the study participants (folate [n=386], hom..

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University of Melbourne Researchers