Journal article

Testing the neutral theory of molecular evolution using genomic data: a comparison of the human and bovine transcriptome

S MacEachern, J McEwan, A Mather, A McCulloch, P Sunnucks, M Goddard

Genetics Selection Evolution | EDP SCIENCES S A | Published : 2006


Despite growing evidence of rapid evolution in protein coding genes, the contribution of positive selection to intra- and interspecific differences in protein coding regions of the genome is unclear. We attempted to see if genes coding for secreted proteins and genes with narrow expression, specifically those preferentially expressed in the mammary gland, have diverged at a faster rate between domestic cattle (Bos taurus) and humans (Homo sapiens) than other genes and whether positive selection is responsible. Using a large data set, we identified groups of genes based on secretion and expression patterns and compared them for the rate of nonsynonymous (dN) and synonymous (dS) substitutions ..

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University of Melbourne Researchers