Journal article

Structured water layers adjacent to biological membranes

Michael J Higgins, Martin Polcik, Takeshi Fukuma, John E Sader, Yoshikazu Nakayama, Suzanne P Jarvis



Water amid the restricted space of crowded biological macromolecules and at membrane interfaces is essential for cell function, though the structure and function of this "biological water" itself remains poorly defined. The force required to remove strongly bound water is referred to as the hydration force and due to its widespread importance, it has been studied in numerous systems. Here, by using a highly sensitive dynamic atomic force microscope technique in conjunction with a carbon nanotube probe, we reveal a hydration force with an oscillatory profile that reflects the removal of up to five structured water layers from between the probe and biological membrane surface. Further, we find..

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University of Melbourne Researchers