Journal article

First international consensus on the methodology of lymphangiogenesis quantification in solid human tumours

I Van der Auwera, Y Cao, JC Tille, MS Pepper, DG Jackson, SB Fox, AL Harris, LY Dirix, PB Vermeulen

BRITISH JOURNAL OF CANCER | NATURE PUBLISHING GROUP | Published : 2006

Abstract

The lymphatic system is the primary pathway of metastasis for most human cancers. Recent research efforts in studying lymphangiogenesis have suggested the existence of a relationship between lymphatic vessel density and patient survival. However, current methodology of lymphangiogenesis quantification is still characterised by high intra- and interobserver variability. For the amount of lymphatic vessels in a tumour to be a clinically useful parameter, a reliable quantification technique needs to be developed. With this consensus report, we therefore would like to initiate discussion on the standardisation of the immunohistochemical method for lymphangiogenesis assessment.