Journal article
Heritability of refractive error and ocular biometrics: The genes in myopia (GEM) twin study
M Dirani, M Chamberlain, SN Shekar, AFM Islam, P Garoufalis, CY Chen, RH Guymer, PN Baird
Investigative Ophthalmology and Visual Science | Published : 2006
DOI: 10.1167/iovs.06-0270
Abstract
PURPOSE. A classic twin study was undertaken to assess the contribution of genes and environment to the development of refractive errors and ocular biometrics in a twin population. METHODS. A total of 1224 twins (345 monozygotic [MZ] and 267 dizygotic [DZ] twin pairs) aged between 18 and 88 years were examined. All twins completed a questionnaire consisting of a medical history, education, and zygosity. Objective refraction was measured in all twins, and biometric measurements were obtained using partial coherence interferometry. RESULTS. Intrapair correlations for spherical equivalent and ocular biometrics were significantly higher in the MZ than in the DZ twin pairs (P < 0.05), when refrac..
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