Journal article

Quantitative retinal venular caliber and risk of cardiovascular disease in older persons - The Cardiovascular Health Study

Tien Yin Wong, Aruna Kamineni, Ronald Klein, A Richey Sharrett, Barbara E Klein, David S Siscovick, Mary Cushman, Bruce B Duncan

ARCHIVES OF INTERNAL MEDICINE | AMER MEDICAL ASSOC | Published : 2006

Abstract

BACKGROUND: Small vessel disease may contribute to the risk of cardiovascular disease in older persons. We describe the relation of retinal vascular caliber to incident coronary heart disease (CHD) and stroke in elderly persons. METHODS: Prospective population-based cohort study composed of 1992 men and women aged 69 to 97 years living in 4 US communities. Retinal arteriolar and venular calibers were measured from retinal photographs using a computer-assisted method. Incident CHD and stroke events were ascertained using standardized methods. RESULTS: After 5 years of follow-up, there were 115 incident CHD events and 113 incident stroke events. Participants with larger retinal venular caliber..

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