Journal article

Class II myosins in nematodes - genetic relationships, fundamental and applied implications

S Nikolaou, M Hu, NB Chilton, D Hartman, AJ Nisbet, PJA Presidente, RB Gasser

BIOTECHNOLOGY ADVANCES | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2006

Abstract

Myosins are represented by a wide range of different classes of molecule, of which the most extensively studied are the class II myosins which drive muscle contraction and cell organization; the functional unit of class II myosins comprises two myosin heavy chains (MHCs). This minireview gives an update on class II MHCs of nematodes and describes a comparative analysis of MHC genes from nematodes and other organismal groups. Genetic analyses of sequence data for the four functional domains of MHCs (i.e., the SH3-like N-terminal, head, neck and tail domains) reveal a delineation between both the nematode and non-nematode myosins and between muscle and non-muscle myosins. The distinctiveness o..

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