Journal article
Short-term effects of methylprednisolone on cerebral volume in multiple sclerosis relapses
C Chapman, N Tubridy, MJ Cook, PJ Mitchell, LR MacGregor, C Lovelock, L Litewka, L Sedal, TJ Kilpatrick, H Butzkueven
Journal of Clinical Neuroscience | ELSEVIER SCI LTD | Published : 2006
Abstract
We prospectively investigated the short-term effects of intravenous methyl-prednisolone (IVMP) on cerebral volume in patients suffering a multiple sclerosis (MS) relapse. Ten patients underwent MRI brain studies immediately before and after IVMP treatment, and 4 and 8 weeks later. Whole brain volumes decreased significantly over the 8-week period. The greatest change occurred during IVMP administration. This has implications for MS treatment trials using cerebral atrophy as an endpoint. © 2006 Elsevier Ltd. All rights reserved.