Journal article

Improved antigen binding by a CD20-specific single-chain antibody fragment with a mutation in CDRH1

PJ Adamson, DJ Millard, AW Hohmann, C Mavrangelos, PJ Macardle, G Pilkington, TD Mulhern, TF Tedder, H Zola, IC Nicholson

Molecular Immunology | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2006

DOI: 10.1016/j.molimm.2005.04.016

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Keywords

Human B-Cells
Phage Display
Rituximab
Life Sciences & Biomedicine
Complementarity Determining Regions
Immunoglobulin Heavy Chains
Immunoglobulin Mutation
Antigen-Antibody Reactions
Immunoglobulin Variable Region
Cd20
Science & Technology
Complementarity Determining Region
Mouse
Biochemistry & Molecular Biology
Single-Chain Antibody Fv Fragment
Fusion Protein
In-Vivo
Therapy
Hybridomas
Humans
Immunoglobulin Fragments
Monoclonal-Antibodies
Models, Molecular
Antigens, Cd20
Mutation
Immunology
Expression
Amino Acid Sequence