Journal article

Frizzled-7 dictates three-dimensional organization of colorectal cancer cell carcinoids

E Vincan, PK Darcy, CA Farrelly, MC Faux, T Brabletz, RG Ramsay

ONCOGENE | NATURE PUBLISHING GROUP | Published : 2007

Abstract

Progression of colorectal cancer (CRC) involves spatial and temporal occurrences of epithelial-mesenchymal transition (EMT), whereby tumour cells acquire a more invasive and metastatic phenotype. Subsequently, the disseminated mesenchymal tumour cells must undergo a reverse transition (mesenchymal-epithelial transition, MET) at the site of metastases, as most metastases recapitulate the pathology of their corresponding primary tumours. Importantly, initiation of tumour growth at the secondary site is the rate-limiting step in metastasis. However, investigation of this dynamic reversible EMT and MET that underpins CRC morphogenesis has been hindered by a lack of suitable in vitro models. To t..

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