Journal article

Testosterone aromatization and cognition in women: a randomized, placebo-controlled trial

Sonal Shah, Robin J Bell, Greg Savage, Rebecca Goldstat, Mary-Anne Papalia, Jayashri Kulkarni, Susan Donath, Susan R Davis

MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY | LIPPINCOTT WILLIAMS & WILKINS | Published : 2006

Abstract

OBJECTIVE: To explore whether inhibition of the conversion of testosterone to estradiol modifies the effects of testosterone on cognition in 61 healthy, estrogen-treated postmenopausal women. DESIGN: Seventy-six postmenopausal women using transdermal estrogen for at least 8 weeks, with a serum total testosterone less than 1.2 nmol/L participated in a single-center, double-blind, randomized, placebo-controlled study. All participants received transdermal testosterone, 400 muL of a 0.5% testosterone gel, daily and were randomized to receive either letrozole 2.5 mg/day or an identical placebo tablet. The main outcome measure was cognition, evaluated using a comprehensive battery of standardized..

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