Journal article

PTEN is recruited to specific microdomains of the plasma membrane during lactacystin-induced neuronal apoptosis

Meng Shyan Choy, Boon Huat Bay, Heung-Chin Cheng, Nam Sang Cheung

NEUROSCIENCE LETTERS | ELSEVIER IRELAND LTD | Published : 2006

Abstract

The tumor suppressor PTEN (phosphatase and tensin homolog deleted from chromosome 10) is a novel phosphatase displaying both protein and lipid phosphatase activities. In the central nervous system, PTEN plays an important role in the regulation of cell growth, differentiation and death. The tumor suppressor function of PTEN is attributed to its phospholipid phosphatase activity that dephosphorylates the plasma membrane phosphatidylinositol-(3,4,5)-triphosphate (PtdIns(3,4,5)P(3)). Since PTEN is normally localized in the cytosol, it needs to be targeted to the plasma membrane to dephosphorylate PtdIns(3,4,5)P(3). We previously demonstrated that lactacystin-induced apoptosis of culture cortica..

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