Journal article

Low mannose-binding lectin function is associated with sepsis in adult patients

Damon P Eisen, Melinda M Dean, Peter Thomas, Penny Marshall, Natalie Gerns, Sue Heatley, Josephine Quinn, Robyn M Minchinton, Jeff Lipman

FEMS Immunology and Medical Microbiology | BLACKWELL PUBLISHING | Published : 2006

Abstract

Mannose-binding lectin (MBL) is an innate immune system pattern recognition molecule that kills a wide range of pathogens via the lectin complement pathway. MBL deficiency is associated with severe infection but the best measure of this deficiency is undecided. We investigated the influence of MBL functional deficiency on the development of sepsis in 195 adult patients, 166 of whom had bloodstream infection and 35 had pneumonia. Results were compared with 236 blood donor controls. MBL function (C4b deposition) and levels were measured by enzyme-linked immunosorbent assay. Using receiver-operator characteristics of MBL function in healthy controls, we identified a level of <0.2 U microL(-1) a..

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