Journal article

Effect of interphase gap and pulse duration on electrically evoked potentials is correlated with auditory nerve survival

Pavel Prado-Guitierrez, Leonie M Fewster, John M Heasman, Colette M Mckay, Robert K Shepherd

Hearing Research | ELSEVIER SCIENCE BV | Published : 2006

Abstract

We investigated the effect of pulse duration (PD) and interphase-gap (IPG) on the electrically-evoked auditory brain stem response (EABR) and viiith nerve compound action potential (ECAP) of deafened guinea pigs in order to test the hypothesis that the extent of change in these neural responses is affected by the histological status of the auditory nerve. Fifteen guinea pigs were deafened by co-administration of kanamycin and furosemide. Animals were acutely implanted with an 8-band electrode array at 1, 4 or 12 weeks following deafening. EABR and ECAP input/output functions were recorded in response to charge balanced biphasic current pulses. We determined the change in current required to ..

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