Journal article

Efficacy of amisulpride in treating primary negative symptoms in first-episode psychosis: a pilot study

Brendan P Murphy, Antonia H Stuart, Darryl Wade, Sue Cotton, Patrick D McGorry

HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL | JOHN WILEY & SONS LTD | Published : 2006

Abstract

OBJECTIVE: Negative symptoms are debilitating and associated with poor role functioning and reduced quality of life. There is a paucity of research on antipsychotic efficacy against the primary negative symptoms, particularly in first-episode psychosis (FEP). We undertook a prospective, open-label pilot trial to investigate the use of amisulpride in the treatment of young people with FEP characterised by primary negative symptoms. METHOD: Twelve male and two female first-episode patients with primary negative symptoms (aged 16-26) were commenced on low-dose amisulpride (mean 250 mg/day) and followed-up over a 6-month period. Primary outcome measures were the Scale for the Assessment of Negat..

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