Journal article

Population genetics study of isoniazid resistance mutations and evolution of multidrug-resistant Mycobactetium tuberculosis

Manzour Hernando Hazbon, Michael Brimacombe, Miriam Bobadilla del Valle, Magali Cavatore, Marta Inirida Guerrero, Mandira Varma-Basil, Helen Billman-Jacobe, Caroline Lavender, Janet Fyfe, Lourdes Garcia-Garcia, Clara Ines Leon, Mridula Bose, Fernando Chaves, Megan Murray, Kathleen D Eisenach, Jose Sifuentes-Osornio, M Donald Cave, Alfredo Ponce de Leon, David Alland

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | AMER SOC MICROBIOLOGY | Published : 2006

Abstract

The molecular basis for isoniazid resistance in Mycobacterium tuberculosis is complex. Putative isoniazid resistance mutations have been identified in katG, ahpC, inhA, kasA, and ndh. However, small sample sizes and related potential biases in sample selection have precluded the development of statistically valid and significant population genetic analyses of clinical isoniazid resistance. We present the first large-scale analysis of 240 alleles previously associated with isoniazid resistance in a diverse set of 608 isoniazid-susceptible and 403 isoniazid-resistant clinical M. tuberculosis isolates. We detected 12 mutant alleles in isoniazid-susceptible isolates, suggesting that these allele..

View full abstract

University of Melbourne Researchers