Journal article

Magnetic resonance imaging of the visual system in vivo: Transsynaptic illumination of V1 and V2 visual cortex

James D Lindsey, Miriam Scadeng, David J Dubowitz, Jonathan G Crowston, Robert N Weinreb

NEUROIMAGE | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2007

Abstract

Brain nuclei directly receiving retinal projections are readily labeled in magnetic resonance images following intraocular injection of manganese (Mn). To assess whether Mn in retinal ganglion cell axons can be transsynaptically delivered to visual cortex, mice that had previously received intraocular Mn injection were anesthetized with isoflurane, and T1-weighted data sets were acquired of the eyes and brain using a 7-T magnetic resonance imaging machine. Image intensity within contralateral brain structures was evaluated by assessing 1) signal-to-noise ratios, 2) mean image intensity, and 3) mean image intensity normalized to facial muscle intensity. Image intensity was increased throughou..

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