Heritability and shared environment estimates for myopia and associated ocular biometric traits: The Genes in Myopia (GEM) family study

Abstract

To examine the familial correlations, heritability (h2) and common environmental components (c2) of myopia and ocular biometric traits (all treated as continuous outcomes) in families collected through the Genes in Myopia (GEM) family study in Australia. A total of 132 pedigrees (723 participants) were recruited for this study. All individuals completed a risk factor questionnaire and underwent a detailed eye examination including spherical equivalent (SphE) and ocular biometric measurements of axial length (AL), anterior chamber depth (ACD) and corneal curvature (CC). Familial correlations were calculated and h2 and c2 were estimated using a variance component model that assumes a multivari..