Combined antagonism of glutamate mGlu5 and adenosine A(2A) receptors interact to regulate alcohol-seeking in rats
Cameron L Adams, Michael S Cowen, Jennifer L Short, Andrew J Lawrence
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY | CAMBRIDGE UNIV PRESS | Published : 2008
Adenosine and glutamate have been implicated as mediators involved in the self-administration of alcohol. In the present study we sought to determine whether adenosine receptors could interact with metabotropic glutamate receptors to regulate operant responding for alcohol and also the integration of the salience of alcohol-paired cues. Alcohol-preferring (iP) rats were trained to self-administer alcohol under operant conditions. The availability of alcohol was paired with an olfactory cue plus a stimulus light. Rats were examined under fixed ratio responding and also following extinction under a cue-induced reinstatement paradigm. Administration of the selective adenosine A2A receptor antag..View full abstract
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Awarded by NHMRC Australia
Founder iP rats were supplied by Professor T. K. Li (while at Indiana University, Indianapolis). Funded by a programme grant (236805) from the NHMRC Australia of which A.J.L. is a Senior Research Fellow.