Journal article

Changes in the serotonergic system in the main olfactory bulb of rats unilaterally deprived from birth to adulthood

C Gomez, JG Brinon, L Orio, MI Colado, AJ Lawrence, FC Zhou, M Vidal, MV Barbado, JR Alonso

JOURNAL OF NEUROCHEMISTRY | BLACKWELL PUBLISHING | Published : 2007

Abstract

The serotonergic system plays a key role in the modulation of olfactory processing. The present study examined the plastic response of this centrifugal system after unilateral naris occlusion, analysing both serotonergic afferents and receptors in the main olfactory bulb. After 60 days of sensory deprivation, the serotonergic system exhibited adaptive changes. Olfactory deprivation caused a general increase in the number of fibres immunopositive for serotonin but not of those immunopositive for the serotonin transporter. HPLC data revealed an increase in serotonin levels but not in those of its major metabolite, 5-hydroxyindole acetic acid, resulting in a decrease in the 5-hydroxyindole acet..

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