Does dopamine dysfunction drive depression?

Abstract

Objective: To examine the evidence that dopamine (DA) dysfunction contributes to melancholic depression. Method: Database (EMBASE, PsychLit and MEDLINE) searches using relevant key words were conducted and citations were scrutinized. Results: In this paper, we assume that the definition of melancholia is contingent upon the presence of psychomotor disturbance (PMD). In melancholic depression PMD comprises both a cognitive and motor component and DA is found to be important in both. DA neurotransmission modulates cognition in particular in attention, adaptation and motivational processes and has a pivotal role in motor function. Conclusion: DA is a credible aetiological candidate for the PMD ..