Journal article

Antitumor activity of dual-specific T cells and influenza virus

A Murphy, JA Westwood, LE Brown, MWL Teng, M Moeller, Y Xu, MJ Smyth, P Hwu, PK Darcy, MH Kershaw

CANCER GENE THERAPY | NATURE PUBLISHING GROUP | Published : 2007

Abstract

Activation and expansion of T cells are important in disease resolution, but tumors do not usually satisfy these immune requirements. Therefore, we employed a novel strategy whereby dual-specific T cells were generated that could respond to both tumor and influenza virus, reasoning that immunization with influenza virus would activate and expand tumor-specific cells, and inhibit tumor growth. Dual-specific T cells were generated by gene modification of influenza virus-specific mouse T cells with a chimeric gene-encoding reactivity against the erbB2 tumor-associated antigen. Dual-specific T cells were demonstrated to respond against both tumor and influenza in vitro, and expanded in vitro in ..

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