Journal article

Low mannose-binding lectin complement activation function is associated with predisposition to Legionnaires' disease

DP Eisen, J Stubbs, D Spilsbury, J Carnie, J Leydon, BP Howden

CLINICAL AND EXPERIMENTAL IMMUNOLOGY | BLACKWELL PUBLISHING | Published : 2007

Abstract

Innate immune system deficiency may predispose to severe infections such as Legionnaires' disease. We have investigated the role of mannose-binding lectin (MBL) deficiency in the Melbourne Aquarium Legionnaires' disease outbreak. Serum samples from patients and controls that were exposed but shown to be uninfected from the Melbourne Aquarium Legionnaires' disease outbreak were tested for MBL function (C4 deposition) and level (mannan-binding). MBL function was lower in Legionnaires' disease cases than in age- and sex-matched uninfected, exposed controls. The frequency of MBL deficiency with C4 deposition < 0.2 U/microl was significantly higher in Legionnaires' disease cases than in controls...

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