Journal article

Evaluation of the effect of SMA-pirarubicin micelles on colorectal cancer liver metastases and of hyperbaric oxygen in CBA mice

Jurstine Daruwalla, Khaled Greish, Mehrdad Nikfarjam, Ian Millar, Cathy Malcontenti-Wilson, Arun K Iyer, Chris Christophi

JOURNAL OF DRUG TARGETING | TAYLOR & FRANCIS LTD | Published : 2007

Abstract

Tetrahydropyranyladriamycin (THP or pirarubicin) destroys tumors via several mechanisms; one of which involves the production of ROS that requires molecular oxygen for its generation. SMA forms stable self-assembled associated micelles with pirarubicin (SMA-pirarubicin), and confers macromolecular characteristics to pirarubicin. This micellar macromolecular drug is selectively delivered to solid tumors via the EPR effect and its preferential tumor accumulation suppresses the systemic toxicity whilst its prolonged high concentration at the site of tumor enhances its efficacy much higher compared to free pirarubicin. Administration of SMA-pirarubicin micelle under HBO can further enhance the d..

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University of Melbourne Researchers