Journal article

Avoidance of Nitrous Oxide for Patients Undergoing Major Surgery

Paul S Myles, Kate Leslie, Matthew TV Chan, Andrew Forbes, Michael J Paech, Philip Peyton, Brendan S Silbert, Elaine Pascoe

Anesthesiology | Ovid Technologies (Wolters Kluwer Health) | Published : 2007


Background Nitrous oxide is widely used in anesthesia, often administered at an inspired concentration around 70%. Although nitrous oxide interferes with vitamin B12, folate metabolism, and deoxyribonucleic acid synthesis and prevents the use of high inspired oxygen concentrations, the consequences of these effects are unclear. Methods Patients having major surgery expected to last at least 2 h were randomly assigned to nitrous oxide-free (80% oxygen, 20% nitrogen) or nitrous oxide-based (70% N2O, 30% oxygen) anesthesia. Patients and observers were blind to group identity. The primary endpoint was duration ..

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