Journal article

Men with Kennedy disease have a reduced risk of androgenetic alopecia

R Sinclair, KJ Greenland, S van Egmond, C Hoedemaker, A Chapman, JD Zajac

BRITISH JOURNAL OF DERMATOLOGY | WILEY | Published : 2007

Abstract

BACKGROUND: Spinal and bulbar muscular atrophy or Kennedy disease (KD) is an X-linked neurodegenerative disease caused by an expansion of a polymorphic tandem CAG repeat within the androgen receptor (AR) gene on chromosomal locus Xq11-q12. The CAG repeat region encodes a polyglutamine tract that, when expanded to above 40 in number, results in KD, a neurodegenerative disease primarily targeting lower motor neurones. KD is also associated with partial androgen insensitivity due to loss of receptor function. Degree of expansion of this repeat region, located in the first exon, is correlated with age at onset and disease severity. Androgenetic alopecia (AGA) is a polygenic trait also associated..

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