Protein-carbohydrate interactions: learning lessons from nature

Abstract

Protein--carbohydrate interactions are at the heart of many important biological processes including signalling, recognition and catalysis. A deeper understanding of these interactions at the molecular level will enable the development of novel, effective and highly selective therapeutics. Glycosyltransferases and glycosidases, carbohydrate-processing enzymes responsible for the synthesis and breakdown of oligosaccharides, have emerged as important targets in the fight against bacterial and fungal pathogenesis, cancer and AIDS. Binding and recognition phenomena are essential processes by which the body exerts control over complex biological functions. In this regard, heparin has retained ong..